The objective of the study is to assess changes of fractional vegetation cover (FVC) in Hanoi megacity in period of 33 years from 1986 to 2016 based on a two endmember spectral mixture analysis (SMA) model using multi-spectral and multi-temporal Landsat-5 TM and -8 OLI images. Landsat TM/OLI images were first radiometrically corrected. FVC was then estimated by means of a combination of Normalized Difference Vegetation Index (NDVI) and classification method. The estimated FVC results were validated using the field survey data. The assessment of FVC changes was finally carried out using spatial analysis in GIS. A case study from Hanoi city shows that: (i) the proposed approach performed well in estimating the FVC retrieved from the Landsat-8 OLI data and had good consistency with in situ measurements with the statistically achieved root mean square error (RMSE) of 0.02 (R 2 =0.935); (ii) total FVC area of 321.6 km 2 (accounting for 9.61% of the total area) was slightly reduced in the center of the city, whereas, FVC increased markedly with an area of 1163.6 km 2 (accounting for 34.78% of the total area) in suburban and rural areas. The results from this study demonstrate the combination of NDVI and classification method using Landsat images are promising for assessing FVC change in megacities.