The article examines changing volumes of emission from vehicles by administrative and municipal districts of Moscow. In Moscow automobile transport is the general source of pollution, it produces more than 93% of allover, and this is the absolute maximum of impact for Russian cities and regions. In 2011-2017, it was the first time when the growth of motorization was noticed against background of reduce of pollution due to modernization of car park and new quality of petrol. Total gross emission from vehicles decreased four times. Shifts in the factors defining spatial specifics of distribution of pollution from vehicles are revealed. Assessments of air pollution based on information of all Moscow streets provides estimations for 93 thousand low-level city areas. One of the research result revealed a high correlation between changes of pollution density and changes in transport infrastructure including developing of public transportation, modernization of car park structure. Spatial uniformity of pollution from vehicles has become the main trend of recent years. Programs of the new housing construction and large-scale projects aimed at the transformation of the districts increase the transport connectivity of the city. Administrative decisions on the traffic intensity reduction in the central districts decrease territorial differentiation of pollution. Transport and planning structure at the level of the city, the district, and the area is the defining characteristic. An attempt to solve the transport problem through the transformation of the street road network complicates the application of innovative techniques for combatting air pollution in Moscow.